Concerning Side Effects of Apoquel in Dogs

Apoquel for Dogs: Could It Be Causing More Harm Than Good?

Hello, I’m Dr. Andrew Jones. Today, I want to discuss a topic that’s been brought up by one of our subscribers – a serious concern regarding the allergy medication Apoquel. Could this popular drug be doing more harm than good to your dog? Let’s dive into the details.

A Subscriber’s Concern: Alarming Side Effects

A subscriber shared their experience after their dog had been on Apoquel for about a year and a half. Their dog developed multiple lumps, tumors, and rear leg tremors, raising the question: could Apoquel be causing these issues? This drug has become the go-to solution for dogs suffering from allergies and itching, often providing quick relief. But at what cost?

What is Apoquel?

Apoquel (oclacitinib) is an immunosuppressant drug, specifically a Janus Kinase (JAK) inhibitor. It works by blocking inflammatory cytokines, the chemicals responsible for triggering the itching associated with allergies. While this sounds like a perfect solution, it’s important to remember that this inflammatory response is a part of the body’s defense mechanism.

The Benefits and Risks of Apoquel

Apoquel can be effective for about 50% of dogs with atopic dermatitis, stopping the itching and providing relief. However, the suppression of the immune system can lead to a variety of side effects. These include gastrointestinal issues (vomiting, diarrhea), lethargy, and, as our subscriber experienced, skin masses or tumors.

More Concerning Side Effects

Apoquel has been reported to cause:

• Decreased white blood cell count
• Worsening of cancer or inducing cancer
• Serious skin parasites (like demodicosis)
• Pneumonia
• Bloody diarrhea
• Recurrent urinary tract and ear infections
• Tremors

While some veterinarians claim these side effects are rare, bone marrow suppression – a condition where the production of red and white blood cells is suppressed – is a serious concern. Interestingly, this isn’t mentioned in the drug’s package insert.

What Happens After Stopping Apoquel?

In some cases, taking your dog off Apoquel may reverse certain side effects. However, as our subscriber mentioned, despite discontinuing the drug, their dog still suffers from rear leg tremors. Additionally, the dog had to undergo surgery to remove lumps and tumors, suggesting that not all side effects disappear once the medication is stopped.

Balancing Relief and Risk

Living with a dog suffering from severe environmental allergies is incredibly challenging. Constant itching, licking, and recurrent ear infections can significantly affect their quality of life. In these cases, Apoquel might seem like the best option, especially when nothing else has worked. However, understanding the potential risks is crucial.

Natural Alternatives to Apoquel

If your dog is dealing with environmental allergies, there are several alternative treatments worth considering before resorting to immunosuppressant drugs like Apoquel. Some of these include:

1. Essential Fatty Acids (Krill Oil)
   A high-quality krill oil supplement, dosed at 500 mg per 50 pounds of body weight twice daily, has been shown to reduce inflammation in allergic dogs.

2. Quercetin (Bioactive Flavonoid)
   Quercetin is often referred to as “nature’s Benadryl" and can help reduce allergy symptoms. The suggested dosage is 50 mg per 15 pounds of body weight daily.

3. Plant Sterols (Beta-Sitosterol)
   Derived from soy, this supplement has been shown to benefit dogs with atopy. Dosage: 50 mg per 20 pounds of body weight once or twice daily.

4. Licorice Root Extract
   This natural corticosteroid alternative provides short-term relief. Dosage: ½ ml of tincture per 20 pounds of body weight twice daily.

5. Probiotics
   A good quality multi-strain probiotic can improve gastrointestinal health and the immune system, which, in turn, helps reduce allergy symptoms. One such option is Dr. Jones’ Ultimate Probiotic Formula for Dogs and Cats.

Addressing Tremors After Apoquel

For dogs that have developed tremors after using Apoquel, like the one shared by our subscriber, certain natural remedies may help:

• Lion’s Mane
  This medicinal mushroom has shown promise in managing tremors. Dosage: 100 mg per 10 pounds of body weight once or twice daily.

• Cannabinoids (CBD and CBG)
  Both CBD and CBG have been extensively studied for their effects on seizure disorders and tremors. A combined cannabinoid blend, dosed at 3 mg per 10 pounds of body weight twice daily, may offer relief.

• Acupressure
  Applying moderate pressure to specific acupressure points, such as GB29, GB30, BL60, and KI3, located near your dog’s hips and base of the tail, can help alleviate tremors.

Should You Use Apoquel for Your Dog?

The decision to use Apoquel is a personal one, depending on your dog’s condition and response to other treatments. While it can be highly effective for some dogs, it’s essential to weigh the potential risks and side effects. I recommend thoroughly exploring natural alternatives before turning to Apoquel. However, if your dog continues to suffer despite trying all other options, it might be worth considering – with close monitoring for side effects.

Final Thoughts

If your dog is experiencing severe allergic reactions, I understand the desperation to find relief. I hope this video has provided some insight into the potential risks and benefits of Apoquel. To our subscriber, I wish your dog a speedy recovery and encourage you to explore some of the alternative treatments mentioned here.

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