Panacur and Antioxidant Vitamins Stop Cancer
The Unexpected Anti-Tumor Effects of Fenbendazole (Panacur) and Supplementary Vitamins
Hello, and welcome back to my channel! If you’re new here, feel free to click the subscribe button and hit the bell to sign up for notifications. Don’t forget, you can click the link directly in the box below to get a copy of my free book.
Can Fenbendazole Really Help Dogs and Cats with Cancer?
You may be surprised to learn that the dewormer known by the brand name Panacur, which is actually called fenbendazole, might have anti-tumor effects for our pets. A fascinating study has shown that it may indeed help dogs and cats with cancer, and I want to share the results with you.
A Surprising Discovery in Lymphoma Research
The study began with researchers examining lymphoma in rodents and investigating how fenbendazole could impact cancer development. These mice had an ongoing worm infestation, and researchers used Panacur (fenbendazole) to treat the worms. Interestingly, a significant portion of these mice, who were grafted with cancer cells, didn’t develop cancer at all. This led the researchers to design a more specific study to understand the effects further.
The Study Design: Three Groups of Mice
The study included three groups of mice:
- The Control Group: 20 mice were grafted with lymphoma cells, and their cancer growth was monitored.
- The Fenbendazole-Only Group: 20 mice were treated with just fenbendazole.
- The Fenbendazole + Antioxidants Group: 20 mice received both fenbendazole and additional antioxidant vitamins.
Significant Inhibition of Tumor Development
The group that received both fenbendazole and antioxidant vitamins showed the most promising results. The combination significantly inhibited tumor development, with a large percentage of the mice showing no signs of cancer growth. In fact, many of the cancer cells disappeared entirely.
How Does Fenbendazole Work?
The researchers postulated that fenbendazole works by targeting a specific growth factor called HIF (hypoxia-inducible factor), which is used by tumor cells to grow. Tumor cells often adapt to grow in areas of low oxygen, and fenbendazole seems to interfere with this process. Additionally, the antioxidant vitamins, particularly vitamins A and E, also help suppress HIF and, in turn, limit the growth of cancer cells.
The Role of Antioxidants
Vitamins A and E were identified as the key antioxidants in the study. The combination of these antioxidants with fenbendazole appeared to create a threshold effect, meaning that the cancer growth was significantly inhibited. This study isn’t entirely new, but it’s gaining attention as more people are exploring alternative cancer treatments for their pets.
What Does This Mean for Your Dog or Cat?
If your dog or cat has cancer, you might be wondering if you should try fenbendazole. The answer isn’t clear-cut, as there isn’t yet an established cancer regimen for pets. However, based on recent studies, a relatively low dose of fenbendazole over a 30 to 60 day period seems promising.
For example, if your dog weighs around 20 pounds (10 kg), the recommended dose would be 100 milligrams of fenbendazole once daily. If your dog weighs 40 pounds, you would give them 200 milligrams once daily. This dosage could be used for 30 to 60 days, depending on the situation.
Supplementing with Antioxidants
As for the antioxidant vitamins, the dosages are varied. A great option for providing additional antioxidant vitamins safely is krill oil. Krill oil is high in both vitamins A and E and also contains astaxanthin, another powerful antioxidant. It’s an easy and safe way to supplement your pet’s diet without the risk of overdosing.
My Approach for Treating Lymphoma in My Pet
If my dog Tula ever developed lymphoma (fingers crossed she never does!), I would treat her with the following:
- Fenbendazole: 100 milligrams (10 mg per kg) once daily for 60 days.
- Krill Oil: 500 milligrams daily (one capsule) for 60 days.
This combination could be a promising way to combat cancer and help inhibit tumor growth.
Why This is Worth Looking Into
The results of this study are incredibly promising, especially considering how cancer cells in the mice disappeared and the large percentage that didn’t develop cancer at all. It’s an area of research that we should be paying more attention to. Antioxidant vitamins like vitamin A, vitamin E, and astaxanthin could play a significant role in cancer treatment, and fenbendazole (Panacur) may be a legitimate alternative therapy.
Thank you for watching! I hope you like Tula’s new haircut—she looks adorable in her little bandana, doesn’t she? Be sure to subscribe by clicking above, hit the bell for notifications, and click the link below to grab a copy of my free book.
Take care, and I’ll see you next time!
What dosage of panacur for a 70# dog
I want to do the low dose daily.
What paste do I use? I am finding paste for horses.
Here is Dr. Jones’ advice on Panacur (fenbendazole) for cancer:
The regimen for cancer is 50mg/kg of body weight (23mg per lb) once daily for 3 days on/ 4 days off. The liquid usually is in 100mg/ml concentration, for example a 50lb dog would receive 11.5ml (1150mg) per day for 3 days on / 4 days off. If giving the granules or packets at 222mg / gram, a 50lb dog would get 5 granules or 5 of the 1g packets (5 g total).
Dr Jones suggests trying this for a month to see if your pet will respond.
The liquid panacur I find on the internet is indicated for horses. Is this the right product to use?
Hi Ruth, any form can be used.
Hi! Doug you know if it’s possible in injection format?
I have an 18 pound cat ( down 10 lbs from 28 lb starting weight). Hes has cancer. I bought the liquid suspension of Safe Guard for goats. (100mg/10% fenbendazole) I am confused about how to dose my cat. I know its 50 mg per kilo but i bought the liquid and its higher concentration. American breeders are telling me 4.1 mililiters but directions on bottle say 0.41 ml. Please help!!
Did you ever get a dose? Im having issues too
For an approximately 20lb cat, the dosage would be 450mg, or 4.5ml of the liquid. Dr. Jones has stated that Panacur is a safe med to give.
Which brand of krill oil? Is there a minimum DHA needed?
Hi Shannon – Dr. Jones’ krill oil is here: https://theomega3supplement.com
Hi my cat had liver cancer, and 2 large tumours on 2 k8ver lobes. Can psnacur be used to treat him?
Yes Panacur can treat cancer issues. Check our video from the link below:
https://youtu.be/6OIavH-QUc8
I just recently found out that my 11 year old cat has lymphoma. Can I treat my cat with
Panacur? My Vet recommended prednisone for appetite inducing. He weighs 10lbs. He is
barely eating. How much should I be giving him?
Thank you so much
Dogs – Lymphoma in Dogs (Conventional Veterinary Medicine)
The “typical” canine lymphoma patient is a middle-aged dog brought to the veterinarian because one or more lumps have been found. The veterinarian rapidly determines that all of the peripheral lymph nodes (those near the skin surface) are enlarged and firm. Usually the dog has not been showing any signs of illness. The next step is a blood panel and urinalysis to more completely assess the patient’s health and one or more lymph nodes are aspirated or biopsied to confirm the diagnosis of lymphoma.
So here we are. We have confirmed lymphoma and we know the average life expectancy for a patient with untreated lymphoma is about 2 months from the time of diagnosis. If this is your dog you probably need some time to absorb the import of the cancer diagnosis. You have many general questions and you know that a decision regarding chemotherapy must be rendered.
We will attempt to cover commonly asked questions owners have at this point.
How did my dog get lymphoma?
We do not know how dogs (or people for that matter) get cancer most of the time. There are many types of cancer and many possible causes of cancer (chemicals in our environment, sun exposure, assorted viruses and infections). There are important genetic factors as well. Cancer starts with one or a small group of cells that have “gone wrong.” It appears that such cells arise in our bodies all the time and we have an assortment of natural mechanisms to destroy these cells before they get out of hand. Sometimes these cancer cells escape our natural mechanisms and cancer develops. It is important to realize that cancer is not contagious and that, as a pet owner, you should not feel that you caused this or brought it on your pet somehow.
Many people feel a need to find blame and latch onto the idea that a household cleaner or pesticide was the cause. This is a natural part of grieving but it is important not to focus on cause unduly. Cause is not relevant to treatment; further, there is no way to verify cause. It is best to concentrate on treatment. At this time, there is no way to know what caused lymphoma development in a given patient.
Can my dog be cured?
Theoretically, yes, but practically speaking no. It is best to focus on a realistic outcome which is the longest possible survival with good quality life. Different treatment protocols are associated with different disease-free intervals.
Does my pet need further tests?
If a biopsy has not been performed, it is a good idea to have one done so as to gain the maximum information about the tumor (whether it is slow or fast growing, what type of lymphocytes are involved etc.) as this information can help predict the response to chemotherapy. In cats, due to the effects of the feline leukemia virus on the bone marrow, a biopsy is absolutely necessary to diagnose lymphoma as there are many other blood diseases that can mimic lymphoma. In the dog, however, a lymph node aspirate is frequently adequate to make the lymphoma diagnosis. Many oncologists will require a biopsy prior to referral.
Other tests that may be recommended include a bone marrow aspirate and/or a spleen or liver aspirate. These tests are needed to stage the disease. Lymphoma is classified by stage:
Stage I: – only one lymph node involved
Stage II: – several lymph nodes in the same general area involved
Stage III: – all peripheral lymph nodes involved
Stage IV: – all peripheral lymph nodes plus the spleen, liver, and/or anterior mediastinum in the chest involved
Stage V: – everything in stage IV plus bone marrow involvement
In cases of lymphoma that are not as straightforward as the classical multicentric lymphoma described above, staging may be more important. Staging used to be done regularly after the initial diagnosis of lymphoma but it has since been found that stage of disease does not impact upon the response to chemotherapy (i.e., it is not true that a stage II will have a better response than a stage IV). The exception is Stage V, the most advanced stage. Patients with stage V lymphoma tend to have a poor response to chemotherapy.
How does lymphoma cause death?
Lymphoma is a rapidly growing malignancy that is able to go and grow anywhere where there is lymph tissue. This is virtually every organ in the body. Eventually, the cancer will infiltrate an organ to such an extent that that organ fails (often this is the bone marrow or the liver). The patient loses his/her appetite, vomits or gets diarrhea, weakens and dies. At some point the tumor becomes resistant to therapy and no further remissions can be obtained.
My dog does not fit the above scenario at all. What are other forms of lymphoma?
Lymphoma is classifed by anatomic area affected. By far, the most common form in the dog is the multicentric form as described above. There are other forms:
* Skin form (also called mycosis fungoides)
* Gastrointestinal form (affecting only the GI tract)
* Leukemia (bone marrow form)
Lymphoma can occur anywhere in the body where there is lymph tissue. At this time, I will concentrate on multicentric lymphoma.
Chemotherapy
The word chemotherapy conjours images of the bald Elizabeth Perkins from The Doctor or the bald and vomiting Campbell Scott in Dying Young. It is unfortunate that many pets (and probably people, too) do not receive chemotherapy based upon these unpleasant images that do not truly represent the current state of treatment response. Chemotherapy simply means therapy using medication, as opposed to therapy using surgery or radiation. We hope that you will open your mind to what decades of research and clinical experience tells us about chemotherapy rather than listening to what Hollywood has to say on the subject. The following are common questions pet owners commonly have regarding chemotherapy for their dog.
My dog is not acting sick in any way. Shouldn’t I wait until she at least feels sick before beginning chemotherapy?
This might seem like a reasonable approach at first glance but let us assure you that it really isn’t. One of the most important factors in determining the quality of remission (i.e., how fast we get remission and how long it lasts) is whether or not the patient is feeling sick at the time chemotherapy is started. When lymphoma patients are staged (see above under “does my pet need further tests”), stages are subcategorized as “a” or “b” (for example, a multicentric lymphoma dog who feels well is in stage IIIa while a multicentric lymphoma dog who is vomiting or not eating is in stage IIIb). You will have a much better chance for long term quality survival if lymphoma is treated while the patient is an “a.”
Should we see an oncologist?
It is never wrong to see a specialist. Lymphoma is such a common malignancy in humans that there are always new drugs, new protocols and experimental therapy that your regular veterinarian may not be familiar with. Seeing a specialist may be the best way to present you with all of your options. If you are interested, ask your veterinarian for a referral.
Will chemotherapy make my dog sick?
Probably not. Nausea or infection are possibilities but most dogs do not experience any such complications. Only 7% of patients require hospitalization due to side effects of chemotherapy. The bottom line here is to know that animals rarely get sick from chemotherapy but that you should know what to do in case of a problem (see later)
Will chemotherapy make my dog lose his hair or go bald?
While whiskers are commonly lost, substantial hair loss is not experienced by animals on chemotherapy for cancer. There are some notable exceptions: breeds that have synchronous hair follicle activity. Most breeds have hairs in all diffferent stages of the growth-shed cycle at the same time. A few breeds have all hairs in the same stage of growth-shed at the same time. The breeds that can have a baldness issue include: the Olde English Sheepdog, the poodle, the lhasa apso, the shih tzu.
How will I know when we have achieved remission?
A patient in remission is indistinguishable from a completely cancer-free patient. The lymph nodes will go down to normal size and if there were any signs of illness related to the cancer, these should resolve. There is approximately a 75% chance of achieving remission regardless of protocol selected.
How will I know when we have lost remission?
The most obvious sign will be that the lymph node enlargement has returned. This means that the cancer is now resistant to the drugs being used and new drugs must be chosen. (This is called a rescue.)
How long will my dog have quality life on chemotherapy?
This depends on what protocol you choose and there are many. There are also many factors that influence how an individual will do relative to the “average” response. Important parameters to note when reviewing a protocol are: 1) the disease-free interval (i.e., how long the patient is free from illness); 2) survival time; 3) typical duration of remission; 4) expense; and 5) scheduling.
Protocols and Studies
Chemotherapy followed by half-body radiation therapy for canine lymphoma: Williams, L.E., Johnson, J.L., Hauck, M.L. Ruslander, D.M., Price, G., and Thrall, D.E. Journal of the American College of Veterinary Internal Medicine. Sept/Oct 2004; 18: 703-709
Half-body radiation involves irradiating the front of the dog’s body two days in a row, waiting 3 weeks, and then irradiating the rear half of the dog’s body for two days in a row. In this study 94 dogs with lymphoma received an 11 week chemotherapy induction using prednisone, L-asparaginase, vincristine, doxorubicin, and cyclophosphamide. Of the 94 dogs receiving chemotherapy, 78% (73 dogs) achieved remission. Of these 73 dogs, 52 underwent half-body radiation as above. Only dogs that had achieved remission were allowed to have radiation. The median remission time for these 52 dogs was 311 days. Thirty-one of these 52 dogs lost remission during the time of the study and twenty of them repeated chemotherapy induction, followed by maintenance chemotherapy (without more radiation). Seventeen out of twenty were able to achieve a second remission. It is not entirely clear whether or not this protocol increased the median remission duration over more routine chemotherapy but the relatively short (11 week) chemotherapy protocol may provide substantial convenience factor for an owner. Another important advantage was the fact that 85% of dog seeking a second remission were able to obtain one. The disadvantage of this protocol is the expense of radiation and the fact that the necessary equipment may not be readily available.
I have a 36 lb standard dachshund. What dose of panacur granules should he get? What would the liquid dosing be. I am confused because other internet sites are suggesting smaller doses then Dr Jones.
Hi Donna, there isn’t a standard protocol, it’s all anecdotal, so all we can do is suggest an amount. At 36lbs (16kg) on the starting regimen it would be 800mer per day on the 3 days on, 4 off schedule. Granules are typically 222mg per pack (or gram), so just over 3 1/2 packets or 3.6 grams. Liquid is typically 100mg/ml, so 8ml of the liquid.
Hello, I appreciate the informative website. My Border Collie has lymphoma and had a very bad reaction to the chemo treatment Vinicristine, due to her MDR1 mutation. She is +/- and a 50% dose was too much for her. Her red blood cell levels sunk to 15%. We gave her a long infusion last night, and again this morning. Thankfully the levels have risen to 17%. If we can get them to 25% over the coming days, we can try again with the cyclophosphamide/prednisolone combination, which is safe for her. This may give her from a few weeks, to a few more months. I am so relieved and even hopeful, as I thought I would lose her last night. I want to try Panacur with vitamin E supphinate and CBD oil. My question is: would this be a safe combination, as I have read that the antioxidant in the vitamin E can diminish the effect of the chemo pills? Another consideration: to hopefully get a positive result from the cyclophosphamide/prednisolone for a little while, and when the cancer cells become resistant, to then start with Panacur & vitamin E, as there will be no further option or hope..? I really appreciate any advice and thank you for taking the time to read this longer message. Best wishes from Scott & Juno in Berlin.
How much Panacure for a dog that is 21 pounds? Thank you so much
21 lbs = 9.5 kg, at 50mg / kg, the dosage would be 475mg per day on the suggested 3 days on, 4 days off schedule.